The “Lipstick Effect” once explained why people bought lipsticks during economic downturns. But with masks covering our smiles, funds shifted elsewhere—toward the neck, the eyes, and anywhere that still showed. Enter 111Skin, the London-based luxury skincare brand redefining indulgence.

Indulge in High-Performance Skincare

If you were tempted by a lockdown splurge, perhaps it was the $400 Y-Lift Neck & Décolleté Serum or the complexion-awakening Space Defence Bright Eye Lift Gel. For those with deeper pockets, the brand’s $2,000 Celestial Black Diamond Collection remains the crown jewel. It includes potent serums, contour gels, retinol oils, multi-acid peels, and vitamin C creams—everything to pamper and protect the skin’s barrier.

Why the lofty price tag? The answer lies in diamond particles that deliver active ingredients deep into the skin. Every formula was created by Dr. Yannis Alexandrides, an esteemed Harley Street plastic surgeon whose breakthrough NAC Y2 complex combines antioxidants, amino acids, and a vitamin C derivative. Originally used to heal post-surgery patients, it now powers skincare for anyone craving results.

Luxury Skincare Products & Treatment Masks from 111Skin

The Science Behind the Glow

The NAC Y2 complex supports cellular repair, calms inflammation with caffeine, and strengthens the skin barrier. An airless pump preserves potency, ensuring each drop stays at its peak.

Dr. Alexandrides—educated in Athens and Miami, trained at Jackson Memorial Hospital—brings surgical expertise to his products. In his practice, he offers everything from buccal fat removals and jaw reductions to laser resurfacing and regenerative facials. While travel restrictions may limit in-person visits, 111Skin’s products bring Harley Street science home.

From Clinic to Counter

The brand has grown to include five ranges and over fifty products, plus Clarity, Intensive, and Reparative booster supplements that support skin from the inside out with probiotics and digestive enzymes.

The NAC Y2 story began when Dr. Yannis placed a collagen sponge infused with the complex under the skin of surgical patients. Healing accelerated. Scars diminished. Skin looked stronger. Results inspired him and his wife, Eva, to launch 111Skin in 2012, translating his medical breakthroughs into luxury skincare.

As the professor explains, “We bring clinically inspired skincare that addresses real-life concerns. Using 20+ years of expertise, we design formulas that replicate in-clinic results while feeling indulgent.”

111Skin Luxury Skincare product

Hero Products and Spa Luxury

Beyond the Y Theorem Repair Serum ($359), the brand is known for its cult masks: the Bio Cellulose Facial Treatment Mask and the Rose Gold Brightening Facial Treatment Mask. These products, along with the flagship healing serum, have secured a loyal celebrity following.

To expand the experience, 111Skin created 111SPA/CLINIC, blending surgical expertise with spa indulgence. Think multi-sensory treatments powered by clinical precision, all designed to deliver visible, transformative results.

Why 111Skin Stands Out

Unlike brands built around a single “hero ingredient,” 111Skin relies on over 40 medical-grade actives in precise combinations. NAC Y2 is its cornerstone, unlocking the body’s own repair mechanisms to create healthier, more radiant skin.

The brand’s ethos is simple: science-led, clinically proven, but wrapped in luxury. It’s Harley Street, delivered to your dressing table.