Best PDRN Sheet Masks in 2026

PDRN face masks are sheet or hydrogel masks that combine DNA-derived ingredients with moisturizers to help skin look hydrated and refreshed. Choosing the best one means considering the full formula, how long it takes to use, and whether it suits your skin’s needs. Rael’s Collagen + PDRN Hydrogel Mask is the top pick for dull, dry skin, thanks to its fragrance-free formula and 30–60-minute wear time.

How We Picked

We compared six PDRN masks across five criteria using published ingredient lists, retailer product pages, and brand documentation. Product specifications reflect publicly available information from brands and retailers.

• Format: We compared sheet masks, hydrogel masks, and other formats to help readers find an option that fits their skincare routine.
• Wear Time: We reviewed each product’s recommended application time, from short treatments to extended or overnight wear.
• Price Per Mask: We calculated the cost per mask based on the listed price and pack size to compare affordability across products.
• Essence per Mask: We compared the stated amount of essence per mask where available. A higher amount does not necessarily mean better absorption or results.
• PDRN Source: We noted whether each formula lists salmon-derived or plant-derived PDRN, helping readers distinguish ingredient sources and their differing evidence bases.

How They Compare

1. Rael Collagen + PDRN Hydrogel Mask

Rael’s Collagen + PDRN Hydrogel Mask is fragrance-free, uses salmon-derived PDRN, and has demonstrated improvements in skin hydration, radiance, and elasticity in a 43-participant clinical study. The two-piece hydrogel carries 34g of essence per mask. It turns from white to translucent as it absorbs, signalling when it’s ready to come off.

• Format: Two-piece hydrogel.
• Wear Time: 30 to 60 minutes, removed when the mask turns from white to translucent.
• Price Per Use: $4.75 per mask.
• Essence per Mask: 34g.
• PDRN Source: Salmon-derived PDRN, listed as Sodium DNA.

What to consider: The two-piece hydrogel and 30–60-minute wear time make this a better fit for a dedicated skincare session than a quick, throw-on-and-go mask.

2. Medicube PDRN Pink Collagen Gel Mask

A pink-tinted hydrogel formulated with 13 peptides alongside salmon-derived PDRN. The US directions call for 3 to 4 hours or overnight wear, which fits a sleep-mask routine.

• Format: Hydrogel.
• Wear Time: 3 to 4 hours or overnight.
• Price Per Use: $4.98 per mask.
• Essence per Mask: 28g.
• PDRN Source: Salmon-derived PDRN, listed as Sodium DNA.
• Clinical Study: No clinical study with a published sample size has been found for this product.

What to consider: Consider another option if you prefer shorter treatments.

3. REJURAN Turnover Mask

REJURAN uses its trademarked c-PDRN at a stated 0.2% concentration. No complete English-language US ingredient list has been published by the brand. The available list is a partial retailer translation.

• Format: Microfiber fabric sheet.
•  Wear Time: 10 to 20 minutes.
• Price Per Use: $5.00 per mask.
• Essence per Mask: 40 ml.
• PDRN Source: Salmon-derived c-PDRN (trademarked), at a stated 0.2% concentration.

What to consider: The full ingredient list is harder to verify from readily available product information.

4. numbuzin No.2 Rose PDRN Collagen Plumping Sheet Mask

This gel-textured pudding sheet mask features rose-derived PDRN, 65% collagen water, 500-Dalton low-molecular-weight collagen, and nine peptides. At $2.40 per mask, it’s the cheapest fragrance-free collagen mask in the comparison.

• Format: Gel-textured pudding sheet
• Wear Time: 10 to 20 minutes.
• Price Per Use: $2.40 per mask.
• Essence per Mask: 33 ml of essence per mask, per the brand.
• PDRN Source: Plant-derived PDRN from rose, listed as Sodium DNA.

What to consider: Consider another option if you specifically want an overnight mask rather than a short-treatment sheet mask.

5. ANUA PDRN Hyaluronic Acid Capsule 100 Serum Mask

This is the mask version of Anua’s PDRN serum: a thin water-gel sheet with salmon PDRN, 11 types of hyaluronic acid, hydrolyzed collagen, niacinamide, and glutathione.

• Format: Thin water-gel sheet
• Wear Time: 10 to 20 minutes.
• Price Per Use: $3.40 per mask.
• Essence per Mask: 23ml.
• PDRN Source: Salmon-derived PDRN, listed as Sodium DNA.

What to consider: The 10-pack format makes this less convenient if you want to try a single mask before committing to a full box.

6. VT Cosmetics PDRN Hydrogel Mask

A two-piece hydrogel made with plant PDRN from wild ginseng, plus squalane, lactobacillus ferment, panthenol, and polyglucuronic acid.

• Format: Two-piece hydrogel.
• Wear Time: 20 to 40 minutes.
• Price Per Use: $5.00 per mask.
• Essence per Mask: 33g.
• PDRN Source: Plant-derived (ginseng) PDRN, listed as Sodium DNA.

What to consider: Consider another option if you prefer a product with a clearly disclosed PDRN concentration.

The Bottom Line

• The top pick: Rael’s Collagen + PDRN Hydrogel for its fragrance-free formula, published 43-participant clinical study, and convenient 30–60-minute wear time.

• Also great: medicube PDRN Pink Collagen Gel Mask, REJURAN Turnover Mask, and numbuzin No.2 Rose PDRN Collagen Plumping Sheet Mask.

• Also consider: ANUA PDRN Hyaluronic Acid Capsule 100 Serum Mask and VT Cosmetics Hydrogel Mask.

Frequently Asked Questions

What is a PDRN sheet mask?

PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient used in skincare formulations to help support smoother, refreshed-looking skin. PDRN sheet masks combine this ingredient with hydrating components in a fabric or hydrogel format that rests against the skin for a recommended period of time. These masks are designed to support hydration and improve the appearance of skin rather than deliver ingredients deep beneath the surface.

Which are the best PDRN sheet masks in 2026?

Among the masks compared, Collagen + PDRN Hydrogel Mask stands out for its fragrance-free, dermatologist-tested formula, 34 g essence, and published clinical results supporting improvements in hydration, radiance, and elasticity. Its two-piece hydrogel design and 30–60-minute wear time make it a convenient option for dry, dull-looking skin. Other masks in the comparison offer different formats, ingredients, and wear times depending on individual preferences.

Are PDRN sheet masks safe for sensitive or acne-prone skin?

PDRN itself has a well-established safety profile in dermatology, where it has been used in clinical wound-healing and post-procedure recovery protocols for decades. For sensitive or acne-prone skin, the more relevant question is what else is in the formula: fragrances, essential oils, and occlusive film-forming agents are the ingredients dermatologists most commonly flag as problematic for reactive skin types. Check the full ingredient list and look for masks that carry a dermatologist-tested label and a confirmed fragrance-free formulation before adding any new active to a sensitive skin routine.